Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jun 30;7:286. doi: 10.3389/fcimb.2017.00286

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017 Guerra, Borgogna, Patel, Sward and Voyich.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

S. aureus produces virulence factors that target different neutrophil bactericidal mechanisms following phagocytosis. Cationic antimicrobial peptides are ineffective toward S. aureus due to the presence of positive charges on the bacterial surface transferred by MprF and DltB. S. aureus secretes virulence factors that degrade antimicrobial proteins and enzymes released into the neutrophil phagosome. In addition, neutrophil reactive oxygen species production is decreased by S. aureus virulence factors that degrade intermediate reactive oxygen species like superoxide and hydrogen peroxide to reduce the formation of the highly bactericidal chemical agent hypochlorous acid. Bacterial components indicated in red. Aur, aureolysin; PRTN3, proteinase 3; CTSG, cathepsin G; SAK, staphylokinase.