Table 2.
Meal stimulation test. Semaglutide: placebo differences in the change from baseline to end of treatment AUC for glucose, glucagon, insulin and C-peptide, shown as absolute fasting and postprandial AUC, and mean postprandial increments
| Fasting state | Breakfast | Lunch | Dinner | Overall | |
|---|---|---|---|---|---|
| Absolute fasting and postprandial response, ETR (95% CI) | AUC0–5h | AUC5–10h | AUC10–15h | AUC0–24h | |
| Glucose | 0.78 (0.74, 0.83) | 0.71 (0.67, 0.76) | 0.79 (0.74, 0.85) | 0.80 (0.75, 0.86) | 0.78 (0.74, 0.82) |
| Glucagon | 0.92 (0.86, 0.99) | 0.86 (0.82, 0.91) | 0.86 (0.81, 0.91) | 0.85 (0.79, 0.91) | 0.88 (0.83, 0.93) |
| Insulin | 1.30 (1.11, 1.53) | 0.95 (0.84, 1.07) | 1.05 (0.94, 1.18) | 0.90 (0.81, 1.01) | 1.01 (0.93, 1.10) |
| C-peptide | 1.23 (1.14, 1.32) | 1.03 (0.96, 1.10) | 1.06 (0.99, 1.14) | 0.97 (0.91, 1.04) | 1.05 (1.00, 1.10) |
| Mean postprandial increment, ETD (95% CI) | – | iAUC0–5h/5 h | iAUC5–10h/5 h | iAUC10–15h/5 h | – |
| Glucose, mmol/l | N/A | −1.11 (−1.52, −0.71) | −0.92 (−1.30, −0.54) | −0.60 (−0.93, −0.28) | N/A |
| Glucagon, ng/l | N/A | −12.86 (−23.38, −2.34) | −5.82 (−13.86, 2.23) | −11.49 (−21.91, −1.06) | N/A |
| Insulin, pmol/l | N/A | −43.47 (−73.06, −13.89) | −15.33 (−50.80, 20.15) | −42.90 (−81.81, −3.99) | N/A |
| C-peptide, nmol/l | N/A | −0.192 (−0.316, −0.067) | −0.086 (−0.229, 0.056) | −0.275 (−0.423, −0.128) | N/A |
iAUC, incremental AUC; N/A, not applicable