Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jun 30;8:421. doi: 10.3389/fphar.2017.00421

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017 Zheng, Feng, Liu, Guo, Gao, Li, Xu, Yan, Yin, Zhang, Liu and Shan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

6-phosphogluconate dehydrogenase (6PGD) expression is upregulated in cisplatin-resistant cells and higher 6PGD gene expression correlates with reduced survival of cancer patients. (A) 6PGD enzyme activity by enzyme activity assay in OV2008, C13^∗, A549, and A549DDP cells. (B) 6PGD mRNA expression levels by qRT-PCR (top) and protein levels by Western blotting (bottom) in OV2008, C13^∗, A549, and A549DDP cells. (C) 6PGD protein levels were analyzed in non-tumor ovarian tissues and ovarian cancer tissues. (D) 6PGD protein levels were analyzed in non-tumor lung tissues and lung SCC, lung adenocarcinoma, and large cell lung cancer tissues. (E,F) Kaplan–Meier analysis of OS rates in 34 ovarian cancer patients (E) and 44 NSCLC patients (F) relative to 6PGD protein expression. Error bars represent mean values ± SD from three replicates of each sample (^∗P < 0.05; ^∗∗P < 0.01; ^∗∗∗P < 0.001).