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. 2017 Jun 30;8:421. doi: 10.3389/fphar.2017.00421

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Copyright © 2017 Zheng, Feng, Liu, Guo, Gao, Li, Xu, Yan, Yin, Zhang, Liu and Shan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miR-206 and miR-613 have rewired cellular metabolism by targeting 6PGD. (A,B) C13^∗(A) and A549DDP (B) cell lines were transfected with Mimic NC, miR-206 and miR-613, respectively. The effects of miRNAs on NADPH/NADP⁺ ratio, lactate production and intracellular ATP levels were determined. (C,D) OV2008 (C) and A549 (D) cell lines were transfected with Inhibitor NC and miR-206 inhibitor and miR-613 inhibitor, respectively. The effects of miRNA inhibitors on NADPH/NADP⁺ ratio, lactate production and intracellular ATP levels were determined. Error bars represent mean values ± SD from three replicates of each sample (^∗P < 0.05; ^∗∗P < 0.01; ^∗∗∗P < 0.001).