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. 2017 Jun 30;8:421. doi: 10.3389/fphar.2017.00421

FIGURE 5.

FIGURE 5

Inhibition of 6PGD can reverse cisplatin resistance in cancer cell lines. (A) OV2008/C13∗ or A549/A549DDP cells were treated with Physcion or DDP alone or in combination and cell proliferation was determined by cell counting. (B) C13∗ and A549DDP cells were treated with a serial constant-ratio combining Physcion and DDP for 48 h. The cell viability-based synergistic effect of Physcion and DDP was analyzed according to approach described by Chou and Talalay. The combination index (CI) smaller than 1 indicates a synergetic effect. (C) C13∗ and A549DDP cells treated with miRNA-206/ miRNA-613 or DDP alone or in combination and cell proliferation was determined by cell counting. (D) OV2008 and A549cells treated with miRNA-206/miRNA-613 inhibitor or DDP alone or in combination and cell proliferation was determined by cell counting. Error bars represent mean values ± SD from three replicates of each sample (∗P < 0.05; ∗∗P < 0.01; ∗∗∗P < 0.001).