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. 2017 Jun 30;8:728. doi: 10.3389/fimmu.2017.00728

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Copyright © 2017 Yang, Xu, Zhang, He and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Infarct size and left ventricle function after myocardial infarction (MI). (A) Representative triphenyltetrazolium chloride staining image. (B,C) Measurement of area at risk and infarct area. Ctrl: un-pretreated mice. Depletion: Clophosome^® injection. Depletion + M (L-C): Clophosome^® injection followed by transfer of M1 macrophages transduced with control lentivirus. Depletion + M (L-S): Clophosome^® injection followed by transfer of M1 macrophages transduced with SESN2 lentiviral activation particles. AAR/LV: area at risk volume relative to left ventricle volume. IA/AAR: infarct area relative to area at risk. N = 6 per group. (D) Mouse survival after MI. (E–I) Evaluation of left ventricle end-systolic diameter (LVESD), LVEDD, FS, ejection fraction (EF), and heart rate by echocardiography 2 weeks after MI. N = 5–6 per group. *p < 0.05; **p < 0.01.