Table 5.
Characteristics of clinical trials on vitamins as the nutritional supplements in AP.
| Reference | Subjects/region | Vitamin(s) tested | Dosage (g/kg BW/day) | Method of assessment | Duration of EN or PN (days) | Mortality (n/N) | DOS (days mean ± SD) | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Cont. | Interv. | Cont. | Interv. | Cont. | Interv. | |||||
| Siriwardena et al. (75) | 43/UK | Vitamin C + N-acetylcysteine, selenium | For vitamin C, 2 g/day for 2 days, 1 g/day (continued for up to day 7) | APACHE | 7 | 7 | 0/21 | 4/22 | 14.3 (15.7) | 20.4 (24.4) |
| Sateesh et al.(76) | 53/India | Vitamin C, N-acetyl cysteine, and antoxyl forte | Vitamin C 500 mg, N-acetyl cysteine 200 mg 8 hourly and antoxyl forte 1 capsule hourly | APACHE CT severity index |
– | – | 0/30 | 1/23 | 10.3 ± 7 | 7.2 ± 5 |
| Du et al. (77) | 84/China | Vitamin C | 10 or 1 g/day (con) | Detection of clinical, biochemical, and immunological markers | 5 | 5 | – | – | 13.45 ± 3.21 | 9.34 ± 4.24 |
| Bansal et al. (78) | 39/India | Vitamin A, vitamin E, vitamin C | Vitamin C (1,000 mg in 100 ml saline), vitamin E (200 mg oral), and vitamin A (10,000 IU) | APACHE CT severity index |
14 | 14 | 2/20 | 0/19 | 15.1 ± 5.43 | 12.8 ± 3.9 |
AP, acute pancreatitis; APACHE, acute physiology and chronic health evaluation; Cont., control; DOS, duration of hospital stay; EN, enteral nutrition; Interv., intervention; PN, parenteral nutrition.