Table 3.
Most frequent differentially expressed genes between ductal carcinoma in situ and invasive ductal carcinoma (IDC)
| Tag | Gene | Description | Locus link | Fold change | P value |
| IDC overexpressed genes | |||||
| TGGAAATGAC | COL1A1 | Collagen type I, alpha 1 | 1277 | 315.4 | 0.0054 |
| ATGTGAAGAG | SPARC | Secreted protein, cysteine-rich (osteonectin) | 6678 | 286.8 | 0.0003 |
| TTTGGTTTTC | COL1A2 | Collagen type I, alpha 2 | 1278 | 210.9 | 0.0084 |
| TTGCTGACTT | COL6A1 | Collagen type VI, alpha 1 | 1291 | 73.9 | 0.0023 |
| TTATGTTTAA | LUM | Lumican | 4060 | 56.7 | 0.0011 |
| TTGGAGATCT | NDUFA4 | NADH dehydrogenase (ubiquinone) | 4697 | 56.4 | 0.0065 |
| CCACAGGGGA | COL3A1 | Collagen type III, alpha 1 | 1281 | 49.4 | 0.0056 |
| ATCTTGTTAC | FN1 | Fibronectin 1 | 2335 | 44.3 | 0.0031 |
| TTGTAATCGT | OAZ1 | Ornithine decarboxylase antizyme 1 | 4946 | 38.6 | 0.0038 |
| TGTAATCAAT | HNRPA1 | Heterogeneous nuclear ribonucleoprotein A1 | 3178 | 38.2 | 0.0039 |
| GGAAGCTAAG | OSF-2 | Osteoblast specific factor 2 (fasciclin I-like) | 10631 | 36.3 | 0.0005 |
| ACCTGTATCC | IFITM3 | Interferon induced transmembrane protein 3 | 10410 | 34.3 | 0.0021 |
| GGAAATGTCA | MMP2 | Matrix metalloproteinase 2 | 4313 | 29.1 | 0.0008 |
| TGCACTTCAA | SPARCL1 | SPARC-like 1 (mast9, hevin) | 8404 | 21.7 | 0.0050 |
| GGAACTTTTA | SULF2 | Sulfatase 2 | 55959 | 19.8 | 0.0017 |
| CTGTTAGTGT | MDH1 | Malate dehydrogenase 1 | 4190 | 18.5 | 0.0026 |
| TATGAATGCT | CSPG2 | Chondroitin sulfate proteoglycan 2 (versican) | 1462 | 18.2 | 0.0017 |
| TCCAAATCGA | VIM | Vimentin | 7431 | 17.7 | 0.0014 |
| TGTAGTTTGA | SKP1A | S-phase kinase-associated protein 1A | 6500 | 16.9 | 0.0013 |
| TAATAAACAG | ASAH1 | n-Acylsphimgosine amidohydrolase | 427 | 16.8 | 0.0085 |
| GCCTCCTCCC | EIF3k | Eukaryotic translation initiation factor 3 | 27335 | 16.8 | 0.0098 |
| GAAACAAGAT | PGK1 | Phosphoglycerate kinase 1 | 5230 | 15.8 | 0.0006 |
| TGCTTTGGGA | TTC11 | tetratricopeptide repeat domain 11 | 51024 | 15.8 | 0.0018 |
| GAAATCAAAA | SIGLEC5 | Sialic acid binding Ig-like lectin 5 | 8778 | 14.7 | 0.0098 |
| ATGTAGTAGT | HNRPD | Heterogeneous nuclear ribonucleoprotein D | 3184 | 14.7 | 0.0025 |
| GACCACCTTT | MFAP2 | Microfibrillar-associated protein 2 | 4237 | 14.4 | 0.0000 |
| ACTTATTATG | DCN | Decorin | 1634 | 13.9 | 0.0007 |
| TCTCTACCCA | APLP2 | Amyloid beta (A4) precursor-like protein 2 | 334 | 13.7 | 0.0076 |
| TGCAATATGC | FBN1 | Fibrillin 1 | 2200 | 13.5 | 0.0037 |
| ATTTCTTCAA | SFRP2 | Secreted frizzled-related protein 2 | 6423 | 13.4 | 0.0030 |
| ATAAAAAGAA | CTSK | Cathepsin K (pycnodysostosis) | 1513 | 13.0 | 0.0003 |
| GTACATTGTA | MGC15737 | Hypothetical protein | 85012 | 12.6 | 0.0011 |
| TGATGTTTGA | DAZAP2 | DAZ associated protein 2 | 9802 | 12.5 | 0.0013 |
| TCCGTGGTTG | BASP1 | Membrane attached signal protein 1 | 10409 | 12.1 | 0.0055 |
| ACTGCTTTAC | DKFZp564I1922 | Adlican | 25878 | 12.0 | 0.0086 |
| TCTGCAATGA | TINP1 | Trasnforming growth factor beta-inducible nuclear protein 1 | 10412 | 12.0 | 0.0033 |
| GTTTCTTCCC | SELH | Selenoprotein H | 2880636 | 11.8 | 0.0037 |
| AATATGCTTT | ATP6V1E1 | ATPase | 529 | 11.6 | 0.0009 |
| TTATGGATCT | SPON2 | Spondin 2, extracellular matrix protein | 10417 | 11.3 | 0.0003 |
| AAAATAAAGA | APEX1 | Nuclease, multifunctional DNA repair enzyme | 328 | 11.3 | 0.0099 |
| TGTGTGTTTG | HIF0 | H1 histone family | 3005 | 11.2 | 0.0029 |
| TATGTTTCAG | PTPN12 | Protein tyrosine phosphatase | 5782 | 11.1 | 0.0003 |
| ACCAAAGCCC | MGC9651 | Hypothetical protein | 114932 | 10.6 | 0.0075 |
| CAAGGATCTA | NICE-3 | NICE-3 protein | 25912 | 10.5 | 0.0057 |
| GACGTCTTAA | PSMA4 | Proteasome subunit, alpha type | 5685 | 10.3 | 0.0038 |
| CAGATAACAT | TOMM20 | Translocase | 9804 | 10.1 | 0.0064 |
| AACTCTTGAA | EIF3S3 | Eukaryotic translation initiation factor 3 | 8667 | 10.0 | 0.0047 |
| TTCTTGGTGT | TRPS1 | Trichorhinophalangeal syndrome I | 7227 | 9.9 | 0.0042 |
| TGCCTTAGTA | DNAJC1 | DNAJ homolog | 64215 | 9.8 | 0.0040 |
| AGACAAGCTG | SFRS5 | Splicing factor | 6430 | 9.4 | 0.0015 |
| ACAAGAATTG | SYPL | Synaptophysin-like protein | 6856 | 9.3 | 0.0027 |
| TACATCCGAA | MTPN | Myotrophin | 136319 | 9.3 | 0.0013 |