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. 2017 Jun 30;8:418. doi: 10.3389/fphar.2017.00418

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Copyright © 2017 Yang and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Chemical structures of prokinetic agents (5-HT4 receptor agonists). (A) Velusetrag, a 5-HT4 receptor agonists, significantly increases intestinal and colonic transit. (B) Prucalopride, a first-in-class dihydro-benzofurancarboxamide derivative, is a highly selective agonist of 5-HT4 receptor. (C) Tegaserod, the first 5-HT4 receptor agonist for short-term IBS-C treatment in women. (D) Naronapride, a highly selective 5-HT4 receptor agonist, significantly accelerates overall colonic transit.