Figure 4. Shared genetic architecture between sleep duration, insomnia symptoms, or excessive daytime sleepiness and 20 behavioral and disease traits.
LD-score regression67 estimates of genetic correlation (rG) of sleep duration, insomnia symptoms, and excessive daytime sleepiness are compared with the summary statistics from 20 publicly available genome-wide association studies of psychiatric and metabolic disorders, immune diseases, and other traits of natural variation. Blue, positive genetic correlation; red, negative genetic correlation, rg values displayed for significant correlations. Larger squares correspond to more significant P values. Genetic correlations that are significantly different from zero after Bonferroni correction are marked with an asterisk, after Bonferroni correction p-value cut-off is 0.0025. All genetic correlations in this report can be found in tabular form in Supplementary Table 12. Abbreviations: BMI=body mass index, BMD=bone mineral density, HOMA-IR= Homeostatic model assessment of insulin resistance. * p<10-3, **p<10-5, ***p<10-7.