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Mechanism of CTL activation induced by inoculation of Nefmut-based DNA vectors.
Notes: Muscle (and possibly other) cells expressing the injected DNA vector release both unmodified and engineered exosomes. These latter, once internalized by APCs induce priming/activation of CD8+ T-lymphocytes specific for the antigens uploaded in engineered exosomes.
Abbreviations: APC, antigen-presenting cell; CTL, cytotoxic T lymphocyte.
