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. 2017 Jun 30;8:465. doi: 10.3389/fphys.2017.00465

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Copyright © 2017 Morton, Care, Kirschenman, Cooke and Davidge.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Constriction and relaxation responses of aorta from advanced maternal age virgin, nulliparous or postpartum rats at 3 months postpartum, or equivalent age in never pregnant controls (~13.5 months old). Constriction to (A) phenylephrine (PE) tended to be increased (p = 0.07) in aorta from nulliparous rats. Inset shows analysis of area under curve (AUC) summary data, n = 5–12; group effect p = 0.07; data analyzed by one-way ANOVA. (B) Relaxation to methylcholine (MCh) was significantly reduced (p = 0.007) in aorta from nulliparous rats compared to virgin and postpartum rats, n = 5–11. Data were analyzed by one-way ANOVA with Tukey's post-test: ^**p < 0.01 nulliparous vs. postpartum and virgin groups.