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. 2017 Jun 30;8:465. doi: 10.3389/fphys.2017.00465

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Copyright © 2017 Morton, Care, Kirschenman, Cooke and Davidge.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of oxidized LDL (oxLDL) and superoxide scavenging on responses to methylcholine (MCh) in aorta from advanced maternal age postpartum rats at 3 months postpartum, or equivalent age in never pregnant (virgin) controls (~13.5 months old). Relaxation to MCh was significantly reduced by oxLDL in aorta from (A) virgin and (C) postpartum rats. Concurrent incubation with pegSOD, a superoxide scavenger, did not significantly prevent inhibition of MCh-induced vasodilation by oxLDL in either group. (B,D) Analysis of pEC₅₀ summary data by one-way ANOVA with Sidak's post-test, ^*p < 0.05, ^***p < 0.001 vs. control; n = 4–11.