Figure 4.

Effect of oxidized LDL (oxLDL) and scavenger receptor inhibitors on responses to methylcholine (MCh) in aorta from advanced maternal age postpartum rats at 3 months postpartum, or equivalent age in never pregnant (virgin) controls (~13.5 months old). (A) Concurrent incubation with either TS20 (LOX-1 inhibitor) or CV-6209 and WEB 2086 (CV, WEB; PAF inhibitors) did not prevent inhibition of MCh-induced vasodilation by oxLDL in virgin rats. (C) In postpartum rats, the presence of CV, WEB did not prevent oxLDL-induced dysfunction; however, in the presence of TS20 MCh-induced relaxation was partially recovered. (B,D) Analysis of pEC₅₀ summary data by one-way ANOVA with Sidak's post-test, ^*p < 0.05, ^**p < 0.01 vs. control; n = 4–11.