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. 2017 May 23;595(13):4227–4243. doi: 10.1113/JP274030

Figure 1. Chronic leptin treatment impairs cardiac function in control but improves cardiac outcomes after TAC mice.

Figure 1

A, representative M‐mode echocardiographic images of sham and TAC mice treated either with vehicle or with leptin. B and C, average ejection fraction (B) and shortening fraction (C), measured by M‐mode echocardiography. Data are the mean ± SEM (n = 6–8 mice). * P < 0.05 and *** P < 0.001 vs. sham vehicle; † P < 0.05 and ††† P < 0.001 vs. TAC vehicle; # P < 0.05 and ## P < 0.01 vs. sham leptin.