Figure 3. Leptin treatment prolonged APD in control mice but reverted it in mice that underwent TAC.

A, representative AP recorded in cardiomyocytes from sham (left) and TAC (right) mice treated either with vehicle or with leptin. B, average APD measured at 20% (left), 50% (middle) and 90% (right) of the repolarization. Data are the mean ± SEM (n = 4–6 mice; n = 18–25 cells). ^*** P < 0.001 vs. sham vehicle; ^††† P < 0.001 vs. TAC vehicle; ^### P < 0.001 vs. sham leptin.