Table 1.
Macroscopic parameters of mice, cell capacitances and cardiac leptin levels
| Sham vehicle | Sham leptin | TAC vehicle | TAC leptin | |
|---|---|---|---|---|
| Body weight (g) | 28.72 ± 2.75 | 27.65 ± 2.44 | 27.99 ± 0.58 | 26.69 ± 1.70 |
| Tibia length (mm) | 22.19 ± 0.12 | 22.0 ± 0.11 | 21.86 ± 0.04 | 21.63 ± 0.09 |
| Heart weight/body weight (mg g–1) | 7.84 ± 0.45 | 7.91 ± 0.39 | 10.23 ± 0.69* | 8.78 ± 0.60† |
| Heart weight/tibia length (mg mm–1) | 10.10 ± 2.35 | 9.89 ± 2.16 | 13.11 ± 2.85* | 11.06 ± 1.98† |
| Leptin concentration in heart | ||||
| homogenates (pg μg–1 protein) | 376.3 ± 15.39 | 477.8 ± 4.95* | 412.5 ± 37.55 | 463.4 ± 29.53* |
| Membrane capacitance (pF) | 182.4 ± 7.5 | 187.2 ± 12.6 | 220.4 ± 9.9*** | 183.4 ± 9.2††† |
Data are expressed as the mean ± SEM (* P < 0.05 and *** P < 0.001 vs. sham vehicle; † P < 0.05 and ††† P < 0.001 vs. TAC vehicle; N = 15, n = 33 sham vehicle; N = 14, n = 23 sham leptin; N = 7, n = 34 TAC vehicle; N = 8, n = 34 TAC leptin). N, number of animals; n, number of cells.