Figure 7. Inhibition of the 5‐HT‐induced inward current in type II cells by the Panx‐1 channel blocker carbenoxolone.

A, the 5‐HT‐induced inward current was reversibly inhibited by 5 μm carbenoxolone (CBX), a Panx‐1 channel blocker (upper dotted line above middle traces); note the block developed gradually over a period of ∼6 min (middle traces). B, summary data for a group of four cells exposed to 5‐HT before, during and after CBX; ^* P < 0.05; ^*** P < 0.001.