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. 2017 Jun 30;8:740. doi: 10.3389/fimmu.2017.00740

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Copyright © 2017 Coutinho, Anjos-Valotta, do Nascimento, Pires, Napimoga, Carvalho, Torres, e Silva and Martins.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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15d-PGJ₂ given via nasal instillation reduces house dust mite extract (HDM)-induced peribronquiolar infiltration of leukocytes. Peribronchiolar mononuclear cells (A), eosinophils (B), and neutrophils (C) were counted in 7–10 bronchioles per mouse. 15d-PGJ₂ (0.7–2.3 µg/mouse) was administered 30 min before HDM exposure during the last week of provocation. All samples for histologic examinations were undertaken 24 h after the last HDM challenge. Each value represents the mean ± SEM from five to seven animals. ⁺P < 0.05 as compared to phosphate-buffered saline (PBS)-challenged group; *P < 0.05 as compared to HDM-challenged group.