Table 3.
Main features of human γδ T-cell subsets in chronic inflammatory manifestations.
| Pathology | Human γδ T-cell subset features | Reference | ||
|---|---|---|---|---|
| Vδ1+ | Vδ2+ | Other Vδ2− (non-Vδ1) | ||
| Myositis | – | Recognition of AA-RS (also targeted by anti-Jo-1 autoantibodies) by a specific clone of Vγ1.3Vδ2− TCR (link between γδ T and B cells) | – | (77) |
| Psoriasis | – | Biomarkers for psoriasis, homing to the skin, production of pro-inflammatory cytokines (IFN-γ, TNF-α, and IL-17A), induction of immune cell recruitment from the circulation, release of growth factors and tissue remodeling | – | (78) |
| Rheumatoid arthritis | – | Antigen presentation capacity of effector-memory Vγ9Vδ2+ T cell stimulated with IPP to CD4+ T cells, secretion of pro-inflammatory cytokines (IFN-γ and IL-17), disease progression | – | (79) |
| Systemic lupus erythematosus | Decrease of CD27+CD25highFoxP3+ immunoregulatory Vδ1+ T cells | – | – | (80) |
AA-RS, aminoacyl-histidyl-tRNA synthetase; IPP, isopentenyl pyrophosphate.