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. 2017 Jun 30;8:768. doi: 10.3389/fimmu.2017.00768

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Copyright © 2017 Xu, Liu, Liu, Zhu, Zhu, Zhang, Ren, Wang, Hu and Su.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GrB-producing regulatory B cells (Bregs) were increased in rheumatoid arthritis (RA) patients with disease remission after therapy. 11 RA patients before and after therapy with disease-modifying antirheumatic drugs were enrolled in the study. (A) The frequencies of GrB-producing Breg were assayed by flow cytometry. The representative flowcharts and statistical results were shown. (B) The disease activity scores 28 (DAS28-ESR) of RA patients before and after therapy were evaluated and analyzed. **P < 0.01, by Wilcoxon signed-rank test. GrB, granzyme B.