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. 2017 Mar 25;6(2):9. doi: 10.3390/cells6020009

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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General chromatin effects of A∆rod and A∆rod∆hbs. (a) DNA staining (DAPI) in U2OS cells expressing A∆rod. Chromatin staining tended to be stronger on or around lamin A∆rod structures. (b) pRb is a known binding partner of lamin A, and so, it was co-stained as a positive control, revealing strong co-localization with the A∆ structures. (c) No co-localization between A∆rod structures and 53BP1 in HeLa cells indicates that chromatin is not damaged by the structures. (d) Similarly, γH2AX did not accumulate on A∆ structures.

General chromatin effects of A∆rod and A∆rod∆hbs. (a) DNA staining (DAPI) in U2OS cells expressing A∆rod. Chromatin staining tended to be stronger on or around lamin A∆rod structures. (b) pRb is a known binding partner of lamin A, and so, it was co-stained as a positive control, revealing strong co-localization with the A∆ structures. (c) No co-localization between A∆rod structures and 53BP1 in HeLa cells indicates that chromatin is not damaged by the structures. (d) Similarly, γH2AX did not accumulate on A∆ structures.