Table 2.
Tumor suppressor and oncogenic long non-coding RNAs (lncRNAs) in lung cancer.
| MicroRNA | Chromosome | Biological Processes |
|---|---|---|
| Tumor suppressor lncRNAs | ||
| MEG3 | 14q32.2 | TP53 up-regulation [97,98] |
| GAS6-AS1 | 13q34 | Unknown |
| BANCR | 9q21.12 | EMT inhibition [101] |
| PANDAR | 6q21.2 | Apoptosis by BCL2 down-regulation [102] |
| Oncogenic lncRNAs | ||
| MALAT1 | 11q13.1 | Cell proliferation, migration, metastasis, and EMT [105] |
| HOTAIR | 12q13.13 | Invasiveness and metastasis by recruiting PRC2 or reorganizing chromatin [109] |
| CCAT2 | 8q24.21 | Cell migration by up-regulating of MYC, miR-17-5p, and miR-20a through TCF7L2-mediated transcription [113] |
EMT, epithelial-mesenchymal transition; lncRNA, long non-coding RNA.