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Active sites of (a) Dabigatran-thrombin (PDB accession: 4YHI) and (b) Apixaban-factor Xa (PDB accession: 2P16). These inhibitors generate specific interactions to their target enzymes to prevent anti-coagulation. The hydrophobic and hydrophobic pharmacophores interact to their target enzymes. Blue, red, and gray represent the nitrogen, oxygen, and carbon atoms
