Figure 5.

Schematic model of DNA protection by Dsup protein from radiation damage. Radiation induces DNA breaks, which could interfere DNA replication and gene expression. Heavily damaged cells lose their proliferative ability and are destined for death. Dsup protein suppresses X-ray induced DNA damage depending on association with nuclear DNA, possibly through physical shielding from, or detoxification of, reactive oxygen species (ROS) generated through indirect radiation effects. Thereby, Dsup protein can improve the radiotolerance of cultured animal cells.