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. 2017 Jun 30;10:212. doi: 10.3389/fnmol.2017.00212

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Copyright © 2017 Alfieri, Sorokina, Adrait, Angelini, Russo, Morellato, Matteoli, Menna, Boeri Erba, McLean, Armstrong, Ala, Buxbaum, Brusco, Couté, De Rubeis, Turco and Defilippi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The p140Cap-interactome within the PSD (A) Clusters in the full PSD network. 60 structural clusters where obtained, including 4 significantly enriched for p140Cap–interacting proteins (purple), magnified in panels B–E. (B) Components of Cluster 7. The cluster is overrepresented with “cytoskeleton organization,” “actin cytoskeleton organization,” and “cell junction assembly” terms and contains p140Cap interactors from Module 3. (C) Components of Cluster 17. This cluster is associated with trans-synaptic signaling and contains p140Cap interacting proteins from Module 3. (D) Components of Cluster 22. The cluster includes the main MAGUK and scaffold proteins and associated with “glutamate receptor signaling pathway,” “endocytosis,” “cell-cell signaling,” and “synaptic transmission” terms and contains the majority of the proteins from Module 1. (E) Components of Cluster 23. The cluster is associated with cell adhesion function and cell junction functions and is enriched with proteins from Module 2.