FIG 10.

Model summarizing the findings of present study. The model depicts the changes at the proximal promoter region of Sox8 at the mrhl RNA binding site (bp −141) upon Wnt signaling activation with respect to the binding of corepressors and the recruitment of β-catenin at the TCF4 binding site (bp −800). The displaced corepressors could be replaced with unknown (?) coactivators. The changes in histone modifications are also shown (Ac, acetylation; Me, methylation). Upon Wnt activation, the upregulation of Sox8 leads to meiotic commitment and differentiation.