Figure 3.

Cl⁻‐dependence of UTP‐induced ΔI _SC responses in RTEC monolayers. (A) Representative I _SC trace demonstrating the effect of Cl⁻ substitution by gluconate on basal I _SC as well as on the UTP‐induced ΔI _SC response. Cl⁻ concentrations are indicated in mmol/L. (B) Statistical summary of basal I _SC upon reducing Cl⁻ concentrations on both sides of the monolayer, and recovery upon return to high Cl⁻ solution. (C) Statistical summary of the effect of Cl⁻ substitution on the UTP‐response. All results are means ± SEM (n = 4 primary cultures). *P < 0.05, **P < 0.01, ***P < 0.001 (two tailed) between cultures exposed to test compounds and controls.