Table 2.

Cardiac function characterization through hemodynamic and echocardiographic studies, and lung weight

	EC‐MR+/+ TAC		EC‐MR−/− TAC
Lung weight	Sham 8.59 ± 0.19	TAC 8.65 ± 0.2	Sham 8.58 ± 0.06	TAC 8.92 ± 0.19
Hemodynamics
Systolic pressure (mmHg)	106.2 ± 2.676	164.5 ± 4.435***	105.4 ± 3.925	163 ± 8.4**
End diastolic pressure (mmHg)	4.44 ± 0.74	14.86 ± 2.834a	5.267 ± 1.317	13.13 ± 3.506
Effective arterial elastance (mmHg/μL)	8.776 ± 2.03	11.27 ± 1.041	8.22 ± 2.934	11.98 ± 1.482
dP/dtmax	9119 ± 468.3	8235 ± 653.1	8861 ± 728.2	7818 ± 761.7
dP/dtmin	−9715 ± 793.2	−8985 ± 1043	−8940 ± 670.7	−8863 ± 655
Tau " (msec)	4.54 ± 0.21	4.625 ± 0.30	4.367 ± 0.37	4.65 ± 0.237
End diastolic volume (μL)	35.78 ± 9.259	42.13 ± 5.101	35.8 ± 11.1	36.79 ± 4.56
End systolic volume (μL)	25.11 ± 5.786	31.91 ± 3.811	23.99 ± 5.615	30.1 ± 3.881
Cardiac output (μL/min)	7544 ± 1890	7136 ± 558.5	7475 ± 2085	5810 ± 815.7
ESPVR (mmHg/μL)	4.078 ± 0.892	4.888 ± 0.763	3.65 ± 0.496	6.135 ± 1.355
PRSW (mmHg/μL)	44.9 ± 11.73	70.02 ± 10.17	65.14 ± 9.932	81.09 ± 16.05
Heart rate (bpm)	490.4 ± 17.57	493.9 ± 10.34	481.7 ± 45.08	449.3 ± 21.27
Echocardiography
End diastolic diameter (mm)	3.88 ± 0.14	3.92 ± 0.12	3.946 ± 0.10	4.05 ± 0.14
End systolic diameter (mm)	2.61 ± 0.19	3.21 ± 0.12	2.99 ± 0.01	3.03 ± 0.21

n = 5 EC‐MR^+/+ Sham, 8 EC‐MR^+/+ TAC, 3 EC‐MR^−/− Sham, 8 EC‐MR^−/− TAC. Mean ± SEM is indicated for each parameter. Statistics D'Agostino & Pearson normality test, followed by unpaired Student's t‐test. **P < 0.01; ***P < 0.005.

ESPVR, end systolic pressure–volume relationship; PRSW, preload recruitable stroke work.

^aVersus Sham per genotype.