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. Author manuscript; available in PMC: 2018 Jul 7.
Published in final edited form as: Eur J Med Chem. 2017 Apr 4;134:62–71. doi: 10.1016/j.ejmech.2017.04.001

Fig. 3.

Fig. 3

Relative inhibitory activity for EPAC2-mediated Rap1b-bGDP exchange. Dose-dependent inhibition of EPAC2 GEF activity by compound 1 (black), 10 (blue), 24 (red), 27 (green), 33 (brown), in the presence of 20 μM cAMP. Relative GEF activity were presented as normalized reaction rate constant (means ± SD, n =3) described in the method.