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. Author manuscript; available in PMC: 2018 Jul 7.
Published in final edited form as: Eur J Med Chem. 2017 Apr 4;134:62–71. doi: 10.1016/j.ejmech.2017.04.001

Table 3.

Apparent IC50 values of substituted 2-(isoxazol-3-yl)-2-oxo-N′-phenyl-acetohydrazonoyl cyanide scaffolds for inhibiting EPAC2 GEF activity.

Compound Rap1b-bGDP EPAC2 IC50 (μM)a
1 4.4 ± 0.5
10 2.2 ± 0.3
14 2.3 ± 0.5
15 3.3 ± 0.8
23 4.5 ± 1.0
24 7.0 ± 0.9
26 2.2 ± 0.3
27 2.3 ± 0.2
31 2.2 ± 0.2
32 2.2 ± 0.4
33 1.9 ± 0.3
a

The values are the mean ± SD of at least three independent experiments.