TABLE 4.
Mean time above the MIC for amoxicillin-clavulanate formulations against MICs for the bacterial strains tested obtained in rat plasma simulating human serum pharmacokinetics and comparison with targets for human serum
| Amoxicillin-clavulanate formulationa | Time above the MIC (% of dosing interval) for MICs of:
|
|||||||
|---|---|---|---|---|---|---|---|---|
| 1 μg/ml
|
2 μg/ml
|
4 μg/ml
|
8 μg/ml
|
|||||
| Rat | Human | Rat | Human | Rat | Human | Rat | Human | |
| 2,000/125 mg b.i.d. (ratio 16:1) | >70 | >70 | 64 | 60 | 50 | 49 | 38 | 35 |
| 1,000/125 mg t.i.d. (ratio 8:1) | 100 | 87.5 | 68 | 80.2 | 48 | 54 | 31 | 35.4 |
| 875/125 mg t.i.d. (ratio 7:1) | 100 | 87.5 | 60 | 71 | 45 | 47.5 | 27 | 25 |
| 875/125 mg b.i.d. (ratio 7:1) | 66 | 58 | 40 | 47.5 | 30 | 32 | 18 | 17 |
| 500/125 mg t.i.d. (ratio 4:1) | 62.5 | 62 | 40 | 52 | 30 | 33.3 | NTb | 12.5 |
a
b.i.d., twice a day; t.i.d., three times a day; o.d., once a day.
b
NT, not tested.