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Papp values for ap → bl and bl → ap transport of glycinamide (40 μM) across Caco-2 cell monolayers
| Temp and pH (ap/bl) | Mean Papp (10−6 cm s−1) ± SDa
|
|
|---|---|---|
| ap → bl | bl → ap | |
| 37°C | ||
| 6.0/7.4 | 1.5 ± 0.1 | 2.3 ± 0.1 |
| 7.4/7.4 | 2.0 ± 0.3 | 2.7 ± 0.1 |
| 4°C | ||
| 6.0/7.4 | 0.13 ± 0.02 | 0.12 ± 0.01 |
| 7.4/7.4 | 0.15 ± 0.03 | 0.12 ± 0.01 |
n = 3 to 11 for each experiment. Differences between the values at 37°C (ap → bl compared to bl → ap and pH gradient compared to no pH gradient) are statistically significant (P < 0.05).
