Table 1.
Adult hippocampal neurogenesis in genetic mouse models with altered central 5-HT levels from embryonic stages or adulthood.
| Adult hippocampal neurogenesis in genetic mouse models with altered central 5-HT levels from embryonic stages | |||||||
|---|---|---|---|---|---|---|---|
| Genetic mouse models | Central 5-HT | Survival of 5-HT+ neurons | Proliferation of NSPCs | Survival of adult-born neurons | Neurogenesis induced by exercise or EE | Maturation of adult-born neurons | References |
| Tph2 KO | Almost lost | Normal | Normal in adult, increased in aged | N.D. | Blocked | N.D. | Alenina et al., 2009; Klempin et al., 2013 |
| Tph2Pet1 CKO | Almost lost | Normal | Normal in adult, increased in aged | N.D. | N.D. | Enhanced dendritic length of adult-born neurons | Jia et al., 2014; Song et al., 2016b |
| Vmat2sert-cre CKO | Almost lost | Normal | Normal in adult | Increased | N.D. | N.D. | Narboux-Neme et al., 2011; Diaz et al., 2013 |
| Lmx1bPet1 CKO | Almost lost | Lost almost all 5-HT+ neurons | Normal in adult, increased in aged | N.D. | N.D. | N.D. | Zhao et al., 2006; Dai et al., 2008; Song et al., 2016b |
| Pet1 KO | Reduced about 80% | Almost normal | Normal in adult, N.D. in aged | Increased | N.D. | N.A. | Hendricks et al., 2003; Krueger and Deneris, 2008; Diaz et al., 2013 |
| Sert KO | Tissue 5-HT reduced, extracellular 5-HT increased | Lost about 50% 5-HT+ neurons | Normal in adult, increased in aged (Schmitt et al., 2007), Increased in adult (Karabeg et al., 2013) | N.D. | N.D. | N.D. | Bengel et al., 1998; Lira et al., 2003; Shen et al., 2004; Schmitt et al., 2007; Karabeg et al., 2013 |
| MaoA/B double KO | Increased | N.D. | Increased in adult, N.D. in aged | N.D. | N.D. | N.D. | Chen et al., 2004; Singh et al., 2013 |
| Adult hippocampal neurogenesis in mouse models with altered 5-HT level exclusively from adulthood | |||||||
| Mouse models | Central 5-HT | Survival of 5-HT+ neurons | Proliferation of NSPCs | Survival of adult-born neurons | Neurogenesis induced by exercise or EE | Maturation of adult-born neurons | References |
| hTM-DTAiPet1 | Almost lost | Lost almost all 5-HT+ neurons | Increased | Increased | N.D. | N.D. | Song et al., 2016a |
| lTM-DTAiPet1 | Reduction about 50% of Tph2+ cells | Lost half of 5-HT+ neurons | Normal | N.D. | N.D. | N.D. | Song et al., 2016a |
| PC/DTR | Almost lost | Lost almost all 5-HT+ neurons | Increased | N.D. | N.D. | Enhanced dendritic length of new-born neurons | Jia et al., 2014; Song et al., 2016b |
| Pet1-CreERT2; Tph2flox/flox CKO | Reduction about 80% of Tph2+ cells | Normal | Increased | N.D. | N.D. | N.D. | Song et al., 2016a |
| Sert RNAi | Increased extracellular 5-HT level | N.D. | Increased | N.D. | N.D. | N.D. | Ferres-Coy et al., 2013 |
EE, enriched environment; N.D., not determined.