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. 2017 Jun 30;8:452. doi: 10.3389/fphys.2017.00452

Figure 2.

Figure 2

Effects of AOAA on rhythmic inspiratory-related activity recorded from the XII nerve root of medullary slice preparations. (A) Representative medullary slice preparation showing the time course of how instantaneous frequency, calculated from the recordings shown (∫XII nerve, top trace), changes following bath application of 1 mM AOAA (indicated by the black arrow). The time scale of the nerve recordings and instantaneous frequency plots are matched. (B,C) Box plots of group data showing the dose-dependent effects of bath-applied AOAA on the XII inspiratory burst frequency (B) and amplitude (C) of AOAA bath-applied alone (n = 7), and, in a different group of slice preparations, in combination with bicuculline (3 μM, n = 7). The effect of bicuculline alone is presented in the control group data set. *indicates significant difference (p < 0.05) compared to control (baseline), #indicates significant difference (p < 0.05) between the indicated doses.