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The Tumor-Nonmalignant signature is validated on the TCGA dataset, which consists of 979 lung tumors and 108 non-malignant lung tissues. The prediction accuracies are 98% for tumors and 100% for non-malignant lung (overall: 98%, Table 1). Many tumor samples have negative scores which could be due to larger stromal infiltration. A score plot for the MDACC dataset, which has tumor samples only, shows an accuracy of 92% (Table 1).
