Table 1.

Adequate organ function laboratory values

System	Laboratory value
Hematological
Absolute neutrophil count	≥1500/mcL
Platelets	≥100,000/mcL
Hemoglobin	≥9 g/dL or ≥5.6 mmol/L without transfusion or EPO dependency (within 7 days of assessment)
Renal
Serum creatinine OR Measured or calculateda creatinine clearance	≤1.5 X upper limit of normal (ULN) OR ≥60 mL/min for subject with creatinine levels >1.5 X institutional ULN
Hepatic
Serum total bilirubin	≤1.5 X ULN OR
	Direct bilirubin ≤ULN for subjects with total bilirubin levels >1.5 ULN
AST (SGOT) and ALT (SGPT)	≤2.5 X ULN OR ≤5 X ULN for subjects with liver metastases
Albumin	≥25 g/L
Coagulation
International normalized ratio (INR) or prothrombin time (PT) Activated partial thromboplastin time (aPTT)	≤1.5 X ULN unless subject is receiving anticoagulant therapy as long as PT or PTT is within therapeutic range of intended use of anticoagulants ≤1.5 X ULN unless subject is receiving anticoagulant therapy as long as PT or PTT is within therapeutic range of intended use of anticoagulants

^aCreatinine clearance should be calculated per institutional standard