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. 2017 Jun 9;3(6):570–579. doi: 10.1021/acscentsci.7b00142

Scheme 1. Rate-Limiting Hydrogen Atom Abstraction Process in SLO-1.

Scheme 1

Hydrogen abstraction occurs at the active site via a PCET reaction,32 from the substrate, linoleic acid, to the ferric hydroxide cofactor. The relative positioning of residues discussed in the text, numbering of backbone carbons, and kinetic parameters for WT SLO are shown for reference.