Table 3.
Minimum inhibitory concentrations (MIC) (mg/L) for the different antibiotics tested.
| EFSA Breakpoint (other Gram +) | GEN | STR | KM | ERY | CLI | VAN | TET | QD | CM | AMP | CPO | LZD |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 | 8 | 16 | 0.5 | 0.25 | 2 | 2 | 0.5 | 2 | 1 | nd | nd | |
| A2-165 | 1.37 ± 0.12 | 96 ± 18.47 | 8.67 ± 1.76 | 0.20 ± 0.08 | 0.016 ± 0 | 0.27 ± 0.05 | 0.016 ± 0 | 0.03 ± 0.01 | 0.08 ± 0.02 | 0.11 ± 0.02 | 9 ± 1 | 1.25 ± 0.25 |
| L2-6 | 4.33 ± 0.88 | 32 ± 7.15 | 0.42 ± 0.08 | 0.10 ± 0.02 | 0.023 ± 0 | 0.47 ± 0.12 | 4.21 ± 0.62 | 0.58 ± 0.46 | 20 ± 5.66 | 0.06 ± 0.03 | 24 ± 4.62 | 0.62 ± 0.12 |
| M21/2 | 4.75 ± 1.49 | 21 ± 4.43 | 51 ± 45 | 0.05 ± 0.01 | 0.016 ± 0 | 0.25 ± 0 | 1.09 ± 0.63 | 0.016 ± 0 | 0.15 ± 0.03 | 0.04 ± 0.03 | 16.67 ± 7.86 | 0.75 ± 0 |
| CNCM I-4540 | 1.25 ± 0.25 | 21.33 ± 2.67 | 122.67 ± 66.83 | 0.11 ± 0.02 | 0.016 ± 0 | 0.71 ± 0.18 | 0.016 ± 0 | 0.011 ± 0.004 | 0.05 ± 0.04 | 0.11 ± 0.02 | 24 ± 4.62 | 0.04 ± 0.06 |
| CNCM I-4541 | 1.62 ± 0.47 | 24 ± 0 | 14 ± 2 | 20 ± 4 | 0.016 ± 0 | 0.125 ± 0 | 8 ± 0 | 0.27 ± 0.24 | 0.17 ± 0.07 | 0.06 ± 0 | 40 ± 8 | 1.25 ± 0.25 |
| CNCM I-4542 | 2.87 ± 1.12 | 23.67 ± 3.26 | 20 ± 4 | 0.11 ± 0.07 | 0.016 ± 0 | 0.67 ± 0.17 | 0.016 ± 0 | 0.016 ± 0 | 0.29 ± 0.40 | 0.08 ± 0.03 | 20.67 ± 7.69 | 3.17 ± 1.42 |
| CNCM I-4543 | 2 ± 0.40 | 16 ± 0 | 20 ± 4 | 0.08 ± 0.02 | 0.016 ± 0 | 0.29 ± 0.04 | 0.2 ± 0.002 | 0.07 ± 0.03 | 0.31 ± 0.09 | 0.12 ± 0 | ≥256 ± 0 | 1.25 ± 0.38 |
| CNCM I-4544 | 6 ± 1.15 | 21.2 ± 7.31 | 100 ± 52.41 | 0.12 ± 0 | 0.016 ± 0 | 0.92 ± 0.08 | 0.016 ± 0 | 0.023 ± 0 | 0.11 ± 0.02 | 0.09 ± 0.02 | 53.33 ± 5.33 | 0.5 ± 0 |
| CNCM I-4546 | 10 ± 66 | 50.67 ± 13.33 | 256 ± 0 | 0.22 ± 0.61 | 0.018 ± 0.002 | 0.56 ± 0.31 | 2.6 ± 0.6 | 0.16+0.07 | 1.25 ± 1.51 | 0.07 ± 0.02 | 24.8 ± 6.24 | 3 ± 1 |
| CNCM I-4573 | 7 ± 1 | 32 ± 0 | 234 ± 21.33 | 0.01 ± 0.03 | 0.024 ± 0.007 | 0.28 ± 0.05 | 0.028 ± 0.003 | 0.04 ± 0.005 | 0.38 ± 0 | 0.25 ± 0 | 22 ± 3.83 | 3.3 ± 0.8 |
| CNCM I-4574 | 1.75 ± 0.25 | 14 ± 0 | 6 ± 2 | 0.07 ± 0.02 | 0.016 ± 0 | 0.25 ± 0 | 0.016 ± 0 | 0.03 ± 0.01 | 0.09 ± 0.02 | 0.22 ± 0.03 | ≥256 ± 0 | 0.5 ± 0.14 |
| CNCM I-4575 | 1.25 ± 0.25 | 5 ± 1 | 4 ± 1 | 0.07 ± 0.01 | 0.016 ± 0 | 0.5 ± 0 | 0.032 ± 0 | 0.03 ± 0.03 | 0.016 ± 0 | 0.084 ± 0.02 | 4.67 ± 1.67 | 0.03 ± 0.01 |
| CNCM I-4644 | 0.91 ± 0.08 | 9.33 ± 1.33 | 135 ± 69.84 | 0.10 ± 0.05 | 0.026 ± 0.01 | 0.23 ± 0.02 | 0.83 ± 0.32 | 0.04 ± 0.01 | 0.079 ± 0.04 | 0.026 ± 0.01 | 9.333 ± 1.33 | 0.58 ± 0.08 |
Gentamicin (GEN), streptomycin (STR), kanamycin (KM), erythromycin (ERY), clindamycin (CLI), vancomycin (VAN), tetracycline (TET), quinupristin/dalfopristin (QD), chloramphenicol (CM), ampicillin (AMP), cefpirome (CPO), and linezolid (LZD). Experiments have been done in triplicate and the results are expressed as the media ± SEM. nd, Not defined. In bold, Resistances.