TABLE 3.
Activity of CPV against GCV- and PFA-resistant isolates of HCMV
| HCMV strain | Mutation(s) | EC50 (μM) ofa:
|
||
|---|---|---|---|---|
| CPV | GCV or PFA | CDV | ||
| C8914-6 | UL97 | 9.9 ± 3.8 | 232 ± 125 | 3.2 ± 3.5 |
| C8805 37-1-1b | ?UL97 | 2.7 ± 0.1 | 26 ± 11 | 0.7 ± 0.2 |
| C9209 1-4-4b | ?UL97 | 1.5 ± 0.7 | 68 ± 34 | 2.1 |
| C8704 9-1-4b | ?UL97 | 0.3 | 18 | 0.4 |
| 759RD100 | UL97, UL54 | 4.5 ± 3.4 | 175 ± 127 | 1.8 ± 1.0 |
| GDGRK17 | UL97 | 2.4 | 7.1 | 1.6 ± 0.3 |
| GDGRP53 | UL54 | 0.8 ± 0.6 | 47 ± 35 | 3.5 ± 3.5 |
| VR4760R | UL54 | 1.6 ± 0.1 | >227 ± 153c | 0.6 ± 0.4 |
| VR4955R | UL54 | 1.7 ± 0.03 | 170 ± 153c | 0.5 ± 0.4 |
a
These results are presented as means ± standard deviations of the results from two assays.
b
Presumed to be UL97 mutants.
c
This result is for PFA.