TABLE 1.

Pulmonary lesions and loss of body weight in rats with pneumonia caused by four S. pneumoniae strains and treated with simulated human treatment-like slow-release amoxicillin therapy

Parametera	Pneumococcal strain (amoxicillin MIC, μg/ml) [no. of animals in untreated/treated group]
	AR30118 (≤0.015) [6/8]	FJD70 (2) [6/6]	AR06016 (4) [10/10]	AR09164 (4) [9/11]
Extent of lung damage (%)
Untreated	49.17 ± 27.18b	42.92 ± 22.58b	49.37 ± 20.93b	38.89 ± 12.80b
Treated	10.47 ± 5.82	18.33 ± 6.74	21.00 ± 8.70	15.11 ± 14.16
Relative lung weight (% of body weight)
Untreated	2.02 ± 0.97b	1.51 ± 0.65b	1.55 ± 0.73b	1.45 ± 0.40b
Treated	0.85 ± 0.10	0.77 ± 0.18	1.00 ± 0.30	0.92 ± 0.25
Loss of body weight (%)
Untreated	13.90 ± 4.92b	8.29 ± 4.04	10.59 ± 6.18	13.10 ± 4.25b
Treated	4.87 ± 2.62	5.10 ± 2.56	8.25 ± 4.78	7.34 ± 6.00

^aValues are means ± SD.

^bValues for untreated versus treated groups are significantly different (P < 0.05).