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2-AA modulates CBP/p300-mediated HAT activity and the acetylation of CBP/p300. (A) HAT activity in nuclear lysate of 2-AA stimulated and 2-AA-tolerized THP-1 cells following 1 h 2-AA stimulation +/– of C646 (n = 3; means ± SDs; p < 0.05, Student’s t-test). (B) Immunoblot showing decreased CBP/p300 acetylation in 2-AA-tolerized THP-1 cells. Data are representative of three independent experiments.
