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Importance of N-myristoylation of neutralized like 1 (neur1) during notch signaling: the binding of jagged 1 ligand to the notch receptor leads to the ubiquitination of functional notch ligand in the thymic stromal cell (signal-sending cell) by myristoylated neur1. The ubiquitination of jagged 1 and subsequent endocytosis and recycling mediated by myristoylated neur1 leads to regeneration of the signal/ligand (jagged 1), thus maintaining ligand–receptor interaction.
