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. 2017 Jun 29;14:24. doi: 10.1186/s12014-017-9160-2

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — General overview of the GH/IGF-I axis. GH is secreted from the anterior pituitary in response to hypothalamic stimulus and has effects on many tissues in the body, including stimulating large amounts of IGF-I secretion by the l and other tissues. Increases in circulating IGF-I negatively impact GH release from the pituitary gland