Table 1.

Proteomic changes in C57BL/6J mice on standard or high-fat diet

Study design	Differentially expressed proteins (gene symbols)
Plasma proteomics of 8 male C57BL/6J mice and age matched controls on standard diet at 2, 4, 8, 12, 16 and 19 months [49]	Increased		Decreased
	INS	TTR	ALB	SAA1
	Igκ	HP	PRDX2
Plasma proteomics of 8 male mice placed on HFD at 3 weeks of age, analyzed at 2, 4, 6, 8, 10, 12, 16 and 20 weeks after diet induction [62]	Increased		Decreased
	INS	KNG
	RBP-4 (isoform-specific increases and decreases)
	TTR (isoform-specific increases and decreases)
	APOA1 (isoform and age specific increases and decreases)
Cardiac proteomics of 5 male mice on HFD at 3 weeks of age analyzed after 8 weeks on diet [28]	Increased		Decreased
	ECH1	NDPK1	TNNT2	CK
	MDH2	CRYAB	ACTC1	IDH3A
			AK1	ATP5B
	DES1 (isoform-specific increases and decreases)
Pancreatic proteomics of 3 male mice per group started on HFD at 3 weeks, sacrificed for analysis over time at 2, 4, 8 and 16 weeks on diet [75]	Increased		Decreased
	REG1	REG2	GSHPX1
Skin proteomics of 4 male mice on HFD at 3 weeks of age analyzed after 16 weeks on diet [29]	Increased		Decreased
	PDI	INS	ALDOA
	KRT77	APOA1	GAPDH
	PRDX6	FABP	TRSF
	NDPK2	APOE
	MDH1	14-3-3 Protein β
	PGAM1	VPS29
	PSMA1	PHB
	LGALS7	TTR
	NDPK1	NDPK2
	Keratin II, type I
	CK (isoform-specific increases and decreases) S100A10 (isoform-specific increases and decreases)
Stomach proteomics of 4 male mice on HFD at 3 weeks of age, analyzed at 16 weeks [84]	Increased		Decreased
	MYL3	PEBP1	ENO1	MDH1
	ATP5A1	LGALS2	PGAM1	MYL2
	LGALS7	APOA1	HSPB1	ALDH3A1
	FABP3	GKN1	CBR3
	LDH2	PRDX2
	ATP5B
	TPI1 (isoform-specific increases and decreases)

Review of proteomic changes in various tissues of C57BL/6J mice fed a high-fat diet. Certain proteins show isoform-specific regulation, where specific isoforms may be down- or up-regulated. A more detailed table containing isoform-specific regulatory patterns can be found in the additional files or in the original text