Table 2.
Proteomic changes in white adipose tissue of humans and WT mice
| Study design | Differentially expressed proteins (gene abbreviations) | |||
|---|---|---|---|---|
| Human adipose tissue | ||||
| Proteomics of 6 subcutaneous white adipose tissue depots (upper abdominal, lower abdominal, thigh, back, flank, and hip) of 6 female subjects [104] | Increased | Decreased | ||
| HB (4 isoforms, back depot) | VIM (3 isoforms depot specific) | ENO1 (flank depot) | HPX (lower versus upper abdominal depot) | |
| ALB (3 isoforms, hip depot) | ATP5B (hip, flank and upper abdominal depots) | HSP 8 (upper abdominal depot, superficial layer) | ||
| HSP-β6 (hip depot, superficial layer) | HSP-60 kDa (hip depot) | SOD (flank depot) | ||
| FABP-4 (2 isoforms, depot and isoform specific increases and decreases) | ||||
| White adipose tissue C57BL/6J mice | ||||
| White adipose tissue (inguinal, retroperitoneal, mesenteric and epididymal) proteomics of 6 male mice analyzed at 12 and 24 months old [105] | Increased at 24 months | Decreased at 24 months | ||
| ATP5B | ENO1 (2 isoforms) | CA-III (2 isoforms) | ANXA5 | |
| PDHE1-B | IDH3α | ALB | HBB (2 isoforms) | |
| E-FABP | CuZn-SOD | INS | HMW adiponectin | |
| ERP29 | PPIA | Total adiponectin | ||
| APOA4 | APOA1 (4 isoforms, 2 depot specific increases) | |||
| VIM | ||||
| ACT | ||||
Proteomic changes in the adipose tissue of human and mouse models, showing depot and isoform specific regulation. For human adipose tissue, the significantly regulated proteins listed are those that are different between depots, not between layers of depots. Differentially expressed proteins between those layers can be found within the original text