Table 4.

Proteomic changes in the serum of acromegalic patients

Study design	Differentially expressed proteins (gene abbreviations)
Acromegaly
Serum proteomics of 8 acromegalic patients (3 females and 5 males), before and 3–6 months after transsphenoidal surgery [149]	Increased	Decreased
	C4B	IGF-I	TTR (2 isoforms)
		HP a2	HBB
		APOA1 (2 isoforms)

Significantly different changes in the serum proteome of acromegalic patients, demonstrating decreased TTR (which was also decreased in bGH mouse plasma) and increased C4B, an inflammatory marker