Table 9.

Proteins regulated by several models of GH excess or deficiency

	GHR−/− WAT	GHR−/− plasma	GH deficiency	rhGH doping serum	bGH plasma	Acromegaly serum	HFD tissues	HFD plasma	Aging plasma	Aging WAT
APOA1	↓		↑	↓		↓	↑ skin, stomach			↑
APOE		↓			↑		↑ Skin
APOA4		↑								↑
TTR	↑			↑	↓	↓		↑	↑	↑
HP		↓	↓		↑	↓			↑
HBB	↑			↓						↓
RBP4		↑			↓			↑
A2M	↓				↑↓

Shared proteins regulated by mouse or human models of GH excess or deficiency, including several apolipoproteins and inflammatory markers. Upward-pointing arrows indicate increased expression, whereas downward-pointing arrows indicate decreased expression. Arrows in both directions represent isoform-specificity, with total levels of the protein unchanged