TABLE 1.

FICi's of 14 clinical isolates per antifungal combination^a

Strain	FICi for the combination:
	AMB-ITC (MIC)	AMB-VRC (MIC)	AMB-CPF		ITC-CPF		VRC-CPF
			MIC	MEC	MIC	MEC	MIC	MEC
CNM-CM-21	2.0	1.0	0.75	0.56	2.0	1.5	0.18	0.14
CNM-CM-22	2.0	1.0	0.75	0.50	2.0	0.28	0.26	0.19
CNM-CM-796	0.75	0.75	1.0	1.0	2.0	0.04	0.50	0.19
CNM-CM-1244	1.0	0.50	0.55	0.55	2.0	0.37	0.62	0.62
CNM-CM-1910	2.0	0.37	0.50	0.50	2.0	0.75	1.50	0.62
CNM-CM-2097	2.0	2.0	1.0	1.0	2.0	0.26	0.55	0.55
CNM-CM-2158	0.75	1.0	0.55	0.41	2.0	0.31	0.55	0.37
CNM-CM-2159	1.0	0.50	1.0	1.0	2.0	0.28	0.62	0.62
CNM-CM-2160	3.0	0.25	0.75	0.26	2.0	0.19	0.28	0.25
CNM-CM-2161	3.0	0.25	0.56	0.50	2.0	0.19	0.55	0.50
CNM-CM-2162	0.75	0.75	1.0	1.0	2.0	0.19	0.18	0.18
CNM-CM-2163	0.55	1.0	1.0	0.55	1.5	1.5	0.50	0.50
CNM-CM-2164	0.75	0.50	1.0	0.55	0.55	0.37	0.26	0.14
CNM-CM-2266	1.0	1.0	1.0	1.0	2.0	1.5	0.55	0.50
Average FICi	1.46	0.77	0.81	0.67	1.86	0.55	0.50	0.38
Number and % synergyb	0/14 (0)	6/14 (42.8)	1/14 (7.1)	5/14 (35.7)	0/14 (0)	10/14 (64.3)	7/14 (50)	10/14 (64.3)

^aFICi values are arithmetic means of six repetitions. AMB, amphotericin B; ITC, itraconazole; VRC, voriconazole; CPF, caspofungin.

^bThe numbers of strains for which the combination showed synergy out of the total number of strains are shown, and the percentage is given in parentheses.