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Receiver operating characteristic curves of HE4 for differentiating patients with ovarian cancer from chronic kidney disease patients. The area under the curve of S-HE4, U-HE4 and R-HE4 are 0.416, 0.948 and 0.915, respectively. HE4, human epididymis protein 4; S-, serum; U-, urine; R-HE4, ratio of urinary-to-serum HE4 level.
